Theanine-Modified Graphene Oxide Composite Films for Neural Stem Cells Proliferation and Differentiation
Joint Authors
Qi, Zhiping
Fu, Chuan
Pan, Su
Chen, Xue
Guo, Wenlai
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The central nervous system (CNS) injury has been a worldwide clinical problem for regenerative medicine.
Nerve tissue engineering is a new strategy for CNS injury.
Among kinds of biomaterials, graphene oxide (GO)-based degradable composite materials are considered to be promising in the field of neurogenesis.
In this study, GO and L-theanine (TH) were combined by chemical grafting to prepare a new PLGA/GO-TH composite material.
X-ray diffraction (XRD), transmission electron microscope (TEM), Fourier-transform infrared spectra (FTIR), contact angle testers, and mechanical testers were performed to obtain characterization of composite materials.
The protein adsorption efficiency of the PLGA/GO-TH films was then evaluated.
Next, the effect of the composite films on neural stem cell (NSC) survival, proliferation, and differentiation was investigated.
Our results indicated that L-theanine was successfully grafted onto GO.
PLGA/GO-TH composite film can significantly improve NSC survival, proliferation, and neuronal differentiation.
Our results demonstrated that the neurogenesis function of a novel PLGA/GO-TH composite film and its potential as a carrier for the further application in the CNS injury.
American Psychological Association (APA)
Qi, Zhiping& Chen, Xue& Guo, Wenlai& Fu, Chuan& Pan, Su. 2020. Theanine-Modified Graphene Oxide Composite Films for Neural Stem Cells Proliferation and Differentiation. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1188391
Modern Language Association (MLA)
Qi, Zhiping…[et al.]. Theanine-Modified Graphene Oxide Composite Films for Neural Stem Cells Proliferation and Differentiation. Journal of Nanomaterials No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1188391
American Medical Association (AMA)
Qi, Zhiping& Chen, Xue& Guo, Wenlai& Fu, Chuan& Pan, Su. Theanine-Modified Graphene Oxide Composite Films for Neural Stem Cells Proliferation and Differentiation. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1188391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188391