The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis
Joint Authors
Ferraccioli, Gianfranco
Flex, Andrea
Biscetti, Federico
Alivernini, Stefano
Tolusso, Barbara
Gremese, Elisa
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a chronic, definitely disabling, and potentially severe autoimmune disease.
Although an increasing number of patients are affected, a key treatment for all patients has not been discovered.
High-mobility group box-1 (HMGB1) is a nuclear protein passively and actively released by almost all cell types after several stimuli.
HMGB1 is involved in RA pathogenesis, but a convincing explanation about its role and possible modulation in RA is still lacking.
Microbiome and its homeostasis are altered in patients with RA, and the microbiota restoration has been proposed to patients with RA.
The purpose of the present review is to analyze the available evidences regarding HMGB1 and microbiome roles in RA and the possible implications of the crosstalk between the nuclear protein and microbiome in understanding and possibly treating patients affected by this harmful condition.
American Psychological Association (APA)
Biscetti, Federico& Flex, Andrea& Alivernini, Stefano& Tolusso, Barbara& Gremese, Elisa& Ferraccioli, Gianfranco. 2017. The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188417
Modern Language Association (MLA)
Biscetti, Federico…[et al.]. The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188417
American Medical Association (AMA)
Biscetti, Federico& Flex, Andrea& Alivernini, Stefano& Tolusso, Barbara& Gremese, Elisa& Ferraccioli, Gianfranco. The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188417