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Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma
Joint Authors
Kuo, Ming-Ling
Liou, Chian-Jiun
Kuo, Chieh-Ying
Huang, Wen-Chung
Chen, Li-Chen
Shen, Jiann-Jong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tomatidine is isolated from the fruits of tomato plants and found to have anti-inflammatory effects in macrophages.
In the present study, we investigated whether tomatidine suppresses airway hyperresponsiveness (AHR) and eosinophil infiltration in asthmatic mice.
BALB/c mice were sensitized with ovalbumin and treated with tomatidine by intraperitoneal injection.
Airway resistance was measured by intubation analysis as an indication of airway responsiveness, and histological studies were performed to evaluate eosinophil infiltration in lung tissue.
Tomatidine reduced AHR and decreased eosinophil infiltration in the lungs of asthmatic mice.
Tomatidine suppressed Th2 cytokine production in bronchoalveolar lavage fluid.
Tomatidine also blocked the expression of inflammatory and Th2 cytokine genes in lung tissue.
In vitro, tomatidine inhibited proinflammatory cytokines and CCL11 production in inflammatory BEAS-2B bronchial epithelial cells.
These results indicate that tomatidine contributes to the amelioration of AHR and eosinophil infiltration by blocking the inflammatory response and Th2 cell activity in asthmatic mice.
American Psychological Association (APA)
Kuo, Chieh-Ying& Huang, Wen-Chung& Liou, Chian-Jiun& Chen, Li-Chen& Shen, Jiann-Jong& Kuo, Ming-Ling. 2017. Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188421
Modern Language Association (MLA)
Kuo, Chieh-Ying…[et al.]. Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188421
American Medical Association (AMA)
Kuo, Chieh-Ying& Huang, Wen-Chung& Liou, Chian-Jiun& Chen, Li-Chen& Shen, Jiann-Jong& Kuo, Ming-Ling. Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188421