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IL-33-ST2 Axis in Liver Disease: Progression and Challenge
Joint Authors
Sun, Zijian
Chang, Binxia
Gao, Miaomiao
Zhang, Jiyuan
Zou, Zhengsheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The new member of the IL-1 family, interleukin-33 (IL-33), participates in the progression of a variety of diseases through binding with its receptor ST2.
Recently, much clinical evidence and experimental data have indicated that IL-33 is associated with various liver diseases.
This review primarily addresses the relationship between IL-33 and several hepatic diseases.
IL-33 can alleviate high-fat diet- (HFD-) induced hepatic steatosis and insulin resistance, and IL-33 acts as an alarmin, which quickly triggers the immune system to respond to virus invasion and toxic damage to the liver.
However, when liver injury is chronic, IL-33 promotes Th2 reactions and hepatic stellate cell (HSC) activity, facilitating progression to liver fibrosis.
The complicated functions of IL-33 should be considered before its clinical application.
American Psychological Association (APA)
Sun, Zijian& Chang, Binxia& Gao, Miaomiao& Zhang, Jiyuan& Zou, Zhengsheng. 2017. IL-33-ST2 Axis in Liver Disease: Progression and Challenge. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188440
Modern Language Association (MLA)
Sun, Zijian…[et al.]. IL-33-ST2 Axis in Liver Disease: Progression and Challenge. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188440
American Medical Association (AMA)
Sun, Zijian& Chang, Binxia& Gao, Miaomiao& Zhang, Jiyuan& Zou, Zhengsheng. IL-33-ST2 Axis in Liver Disease: Progression and Challenge. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188440