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Role of ARPC2 in Human Gastric Cancer
Joint Authors
Zhang, Jun
Liu, Yi
Yu, Chang-Jun
Dai, Fu
Xiong, Jie
Li, Hong-Jun
Ding, Rui
Wang, Hong
Wu, Zheng-Sheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gastric cancer continues to be the second most frequent cause of cancer deaths worldwide.
However, the exact molecular mechanisms are still unclear.
Further research to find potential targets for therapy is critical and urgent.
In this study, we found that ARPC2 promoted cell proliferation and invasion in the human cancer cell line MKN-28 using a cell total number assay, MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) assay, cell colony formation assay, migration assay, invasion assay, and wound healing assay.
For downstream pathways, CTNND1, EZH2, BCL2L2, CDH2, VIM, and EGFR were upregulated by ARPC2, whereas PTEN, BAK, and CDH1 were downregulated by ARPC2.
In a clinical study, we examined the expression of ARPC2 in 110 cases of normal human gastric tissues and 110 cases of human gastric cancer tissues.
ARPC2 showed higher expression in gastric cancer tissues than in normal gastric tissues.
In the association analysis of 110 gastric cancer tissues, ARPC2 showed significant associations with large tumor size, lymph node invasion, and high tumor stage.
In addition, ARPC2-positive patients exhibited lower RFS and OS rates compared with ARPC2-negative patients.
We thus identify that ARPC2 plays an aneretic role in human gastric cancer and provided a new target for gastric cancer therapy.
American Psychological Association (APA)
Zhang, Jun& Liu, Yi& Yu, Chang-Jun& Dai, Fu& Xiong, Jie& Li, Hong-Jun…[et al.]. 2017. Role of ARPC2 in Human Gastric Cancer. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188452
Modern Language Association (MLA)
Zhang, Jun…[et al.]. Role of ARPC2 in Human Gastric Cancer. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188452
American Medical Association (AMA)
Zhang, Jun& Liu, Yi& Yu, Chang-Jun& Dai, Fu& Xiong, Jie& Li, Hong-Jun…[et al.]. Role of ARPC2 in Human Gastric Cancer. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188452