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Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Regulatory T (Treg) cells maintain immune homeostasis by suppressing excessive immune responses.
Treg cells induce tolerance against self- and foreign antigens, thus preventing autoimmunity, allergy, graft rejection, and fetus rejection during pregnancy.
However, Treg cells also infiltrate into tumors and inhibit antitumor immune responses, thus inhibiting anticancer therapy.
Depleting whole Treg cell populations in the body to enhance anticancer treatments will produce deleterious autoimmune diseases.
Therefore, understanding the precise nature of tumor-infiltrating Treg cells is essential for effectively targeting Treg cells in tumors.
This review summarizes recent results relating to Treg cells in the tumor microenvironment, with particular emphasis on their accumulation, phenotypic, and functional properties, and targeting to enhance the efficacy of anticancer treatment.
American Psychological Association (APA)
Lee, Gap Ryol. 2017. Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188455
Modern Language Association (MLA)
Lee, Gap Ryol. Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188455
American Medical Association (AMA)
Lee, Gap Ryol. Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188455