Adipokine Contribution to the Pathogenesis of Osteoarthritis
Joint Authors
Ramos-Ávalos, Bárbara
Hernández-Molina, Gabriela
Azamar-Llamas, Daniel
Furuzawa-Carballeda, Janette
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-09
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
Recent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA).
However, joint overload is not the only risk factor in this disease.
For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors may also contribute to its pathogenesis.
Recently, white adipose tissue (WAT) has been recognized not only as an energy reservoir but also as an important secretory organ of adipokines.
In this regard, adipokines have been closely associated with obesity and also play an important role in bone and cartilage homeostasis.
Furthermore, drugs such as rosuvastatin or rosiglitazone have demonstrated chondroprotective and anti-inflammatory effects in cartilage explants from patients with OA.
Thus, it seems that adipokines are important factors linking obesity, adiposity, and inflammation in OA.
In this review, we are focused on establishing the physiological mechanisms of adipokines on cartilage homeostasis and evaluating their role in the pathophysiology of OA based on evidence derived from experimental research as well as from clinical-epidemiological studies.
American Psychological Association (APA)
Azamar-Llamas, Daniel& Hernández-Molina, Gabriela& Ramos-Ávalos, Bárbara& Furuzawa-Carballeda, Janette. 2017. Adipokine Contribution to the Pathogenesis of Osteoarthritis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-26.
https://search.emarefa.net/detail/BIM-1188457
Modern Language Association (MLA)
Azamar-Llamas, Daniel…[et al.]. Adipokine Contribution to the Pathogenesis of Osteoarthritis. Mediators of Inflammation No. 2017 (2017), pp.1-26.
https://search.emarefa.net/detail/BIM-1188457
American Medical Association (AMA)
Azamar-Llamas, Daniel& Hernández-Molina, Gabriela& Ramos-Ávalos, Bárbara& Furuzawa-Carballeda, Janette. Adipokine Contribution to the Pathogenesis of Osteoarthritis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-26.
https://search.emarefa.net/detail/BIM-1188457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188457