The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy
Joint Authors
Natale, F.
Crisci, Mario
Calabrò, Paolo
Gragnano, Felice
Sperlongano, Simona
Golia, Enrica
Bianchi, Renatomaria
Fimiani, Fabio
Pariggiano, Ivana
Diana, Vincenzo
Carbone, Andreina
Cesaro, Arturo
Concilio, Claudia
Limongelli, Giuseppe
Russo, Mariagiovanna
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of vascular inflammation.
Recent studies highlight the involvement of VWF and its regulator, ADAMTS13, in mechanisms that underlie vascular inflammation and immunothrombosis, like leukocyte rolling, adhesion, and extravasation; vascular permeability; ischemia/reperfusion injury; complements activation; and NETosis.
The VWF/ADAMTS13 axis is implicated in the pathogenesis of atherosclerosis, promoting plaque formation and inflammation through macrophage and neutrophil recruitment in inflamed lesions.
Moreover, VWF and ADAMTS13 have been recently proposed as prognostic biomarkers in cardiovascular, metabolic, and inflammatory diseases, such as diabetes, stroke, myocardial infarction, and sepsis.
All these features make VWF an attractive therapeutic target in thromboinflammation.
Several lines of research have recently investigated “tailor-made” inhibitors of VWF.
Results from animal models and clinical studies support the potent anti-inflammatory and antithrombotic effect of VWF antagonism, providing reassuring data on its safety profile.
This review describes the role of VWF in vascular inflammation “from bench to bedside” and provides an updated overview of the drugs that can directly interfere with the VWF/ADAMTS13 axis.
American Psychological Association (APA)
Gragnano, Felice& Sperlongano, Simona& Golia, Enrica& Natale, F.& Bianchi, Renatomaria& Crisci, Mario…[et al.]. 2017. The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188466
Modern Language Association (MLA)
Gragnano, Felice…[et al.]. The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy. Mediators of Inflammation No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1188466
American Medical Association (AMA)
Gragnano, Felice& Sperlongano, Simona& Golia, Enrica& Natale, F.& Bianchi, Renatomaria& Crisci, Mario…[et al.]. The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188466