Preparation of a Novel Thiol Surface Modifier and Fe3O4 Drug Loading Agent as well as Releasing under pH-Sensitivity
Joint Authors
Li-Wu, Zu
Ya-zhen, Wang
Yu-tao, Di
Tian-yu, Lan
Ya-zhen, Wang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-08
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In this paper, in order to take advantage of the combination between magnetic nano-Fe3O4 and surface modifier, a pH-sensitive drug delivery system that could effectively deliver doxorubicin (DOX) to tumor tissue was constructed.
The novel drug delivery system named Fe3O4-TIPTS-g-(PEI-co-PEG) was prepared through three steps.
The first step, a surface modifier with the thiol group, thiohydrazide-iminopropyltriethoxysilane surface modifier (named TIPTS), was synthesized for the first time.
The second step, Fe3O4-TIPTS was synthesized by treating nano-Fe3O4 with TIPTS.
The last step, Fe3O4-TIPTS-g-(PEI-co-PEG) was synthesized in the presence of the Fe3O4-TIPTS, polyethyleneimine (PEI), and polyethylene glycol (PEG) by mercapto-initiated radical polymerization.
Among them, magnetic nanoparticles (MNPs) were used as magnetically responsive carriers, PEG was the surface-modifying compound, and PEI was the drug loading site which primary amine reacts with doxorubicin (DOX).
Targeted nanoparticles were considerably stabilize in various physiological solutions and exhibited pH-sensitive performance in drug release.
Thence, Fe3O4-TIPTS-g-(PEI-co-PEG) is a promising nanocarrier for targeting tumor therapy.
American Psychological Association (APA)
Ya-zhen, Wang& Ya-zhen, Wang& Yu-tao, Di& Tian-yu, Lan& Li-Wu, Zu. 2020. Preparation of a Novel Thiol Surface Modifier and Fe3O4 Drug Loading Agent as well as Releasing under pH-Sensitivity. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1188476
Modern Language Association (MLA)
Ya-zhen, Wang…[et al.]. Preparation of a Novel Thiol Surface Modifier and Fe3O4 Drug Loading Agent as well as Releasing under pH-Sensitivity. Journal of Nanomaterials No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1188476
American Medical Association (AMA)
Ya-zhen, Wang& Ya-zhen, Wang& Yu-tao, Di& Tian-yu, Lan& Li-Wu, Zu. Preparation of a Novel Thiol Surface Modifier and Fe3O4 Drug Loading Agent as well as Releasing under pH-Sensitivity. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1188476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188476