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Enhanced Cell Proliferation and Osteogenesis Differentiation through a Combined Treatment of Poly-L-Lysine-Coated PLGAGraphene Oxide Hybrid Fiber Matrices and Electrical Stimulation
Joint Authors
Qi, Zhiping
Yang, Xiaoyu
Xue, Pan
Pan, Su
Zhu, Jiaqi
Zheng, Changjun
Fu, Chuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Bone tissue engineering scaffold provides an effective treatment for bone defect repair.
Biodegradable bone scaffold made of various synthetic and natural materials can be used as bone substitutes and grafts for defect site, which has great potential to support bone regeneration.
Regulation of cell-scaffold material interactions is an important factor for modulating the cellular activity in bone tissue engineering scaffold applications.
Thus, the hydrophilic, mechanical, and chemical properties of scaffold materials directly affect the results of bone regeneration and functional recovery.
In this study, a poly-L-lysine (PLL) surface-modified poly(lactic-co-glycolic acid) (PLGA)/graphene oxide (GO) (PLL-PLGA/GO) hybrid fiber matrix was fabricated for bone tissue regeneration.
Characterization of the resultant hybrid fiber matrices was done using scanning electron microscopy (SEM), contact angle, and a material testing machine.
According to the results obtained from the test above, the PLL-PLGA/GO hybrid fiber matrices exhibited high wettability and mechanical strength.
The special surface characteristics of PLL-PLGA/GO hybrid fiber matrices were more beneficial for protein adsorption and inhibit the proliferation of pathogens.
Moreover, the enhanced regulation of MC3T3-E1 cell proliferation and differentiation was observed, when the resultant hybrid fiber matrices were combined with electrical stimulation (ES).
The cellular response of MC3T3-E1 cells including cell adhesion, proliferation, alkaline phosphatase (ALP) activity, calcium deposition, and osteogenesis-related gene expression was significantly enhanced with the synergistic effect of resultant hybrid fiber matrices and ES.
These data indicate that the PLL-PLGA/GO hybrid fiber matrices supported the cellular response in terms of cell proliferation and osteogenesis differentiation in the presence of electrical stimulation, which could be a potential treatment for bone defect.
American Psychological Association (APA)
Zhu, Jiaqi& Qi, Zhiping& Zheng, Changjun& Xue, Pan& Fu, Chuan& Pan, Su…[et al.]. 2020. Enhanced Cell Proliferation and Osteogenesis Differentiation through a Combined Treatment of Poly-L-Lysine-Coated PLGAGraphene Oxide Hybrid Fiber Matrices and Electrical Stimulation. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1188483
Modern Language Association (MLA)
Zhu, Jiaqi…[et al.]. Enhanced Cell Proliferation and Osteogenesis Differentiation through a Combined Treatment of Poly-L-Lysine-Coated PLGAGraphene Oxide Hybrid Fiber Matrices and Electrical Stimulation. Journal of Nanomaterials No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1188483
American Medical Association (AMA)
Zhu, Jiaqi& Qi, Zhiping& Zheng, Changjun& Xue, Pan& Fu, Chuan& Pan, Su…[et al.]. Enhanced Cell Proliferation and Osteogenesis Differentiation through a Combined Treatment of Poly-L-Lysine-Coated PLGAGraphene Oxide Hybrid Fiber Matrices and Electrical Stimulation. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1188483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188483