Enhanced Crystallinity and Antibacterial of PHBV Scaffolds Incorporated with Zinc Oxide
Joint Authors
Peng, Shuping
Shuai, Cijun
Yang, Wenjing
He, Chongxian
Wang, Guoyong
Qi, Fangwei
Wang, Chen
Qian, Guowen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) has a great potential in bone repair, but unfortunately, the poor mechanical properties limit its further application.
In this work, zinc oxide (ZnO) nanoparticles were incorporated into PHBV porous scaffold fabricated by selective laser sintering technique.
It was because ZnO nanoparticles could provide nucleating sites for the orderly stacking of polymer chains, thereby enhancing the crystallinity of PHBV.
It was well known that the mechanical properties of PHBV scaffold could be enhanced with the increase of crystallinity.
More significantly, the released Zn2+ would combine negatively charged cell membranes of bacterial through electrostatic interaction and consequently destructed the protein structure and resulted in the death of bacterial, which was highly desired in reducing the risk of implant infection.
Results indicated that the relative crystallinity of scaffold with 3 wt.% ZnO increased remarkably from 38% to 64% compared to pure PHBV scaffold, which effectively enhanced the compression strength and modulus by 56% and 51.5%, respectively.
Moreover, the scaffold had a favorable antibacterial activity.
Cell culture experiments proved that the scaffold could promote the cell behaviors.
The positive results demonstrated the scaffold may serve as a potential replacement in bone repair.
American Psychological Association (APA)
Shuai, Cijun& Wang, Chen& Qi, Fangwei& Peng, Shuping& Yang, Wenjing& He, Chongxian…[et al.]. 2020. Enhanced Crystallinity and Antibacterial of PHBV Scaffolds Incorporated with Zinc Oxide. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188486
Modern Language Association (MLA)
Shuai, Cijun…[et al.]. Enhanced Crystallinity and Antibacterial of PHBV Scaffolds Incorporated with Zinc Oxide. Journal of Nanomaterials No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1188486
American Medical Association (AMA)
Shuai, Cijun& Wang, Chen& Qi, Fangwei& Peng, Shuping& Yang, Wenjing& He, Chongxian…[et al.]. Enhanced Crystallinity and Antibacterial of PHBV Scaffolds Incorporated with Zinc Oxide. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188486