![](/images/graphics-bg.png)
A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kBErk 12 and NALP3ASCCaspase-1 Activation in Human THP-1 Monocyte
Joint Authors
Mezzasoma, Letizia
Talesa, Vincenzo Nicola
Antognelli, Cinzia
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Interleukin-1β (IL-1β) is a pleiotropic cytokine and a crucial mediator of inflammatory and immune responses.
IL-1β processing and release are tightly controlled by complex pathways such as NF-kB/ERK1/2, to produce pro-IL-1β, and NALP3/ASC/Caspase-1 inflammasome, to produce the active secreted protein.
Dysregulation of both IL-1β and its related pathways is involved in inflammatory/autoimmune disorders and in a wide range of other diseases.
Identifying molecules modulating their expression is a crucial need to develop new therapeutic agents.
IL-1β is a strong regulator of Brain Natriuretic Peptide (BNP), a hormone involved in cardiovascular homeostasis by guanylyl cyclase Natriuretic Peptide Receptor (NPR-1).
An emerging role of BNP in inflammation and immunity, although proposed, remains largely unexplored.
Here, we newly demonstrated that, in human THP-1 monocytes, LPS/ATP-induced IL-1β secretion is strongly inhibited by BNP/NPR-1/cGMP axis at all the molecular mechanisms that tightly control its production and release, NF-kB, ERK 1/2, and all the elements of NALP3/ASC/Caspase-1 inflammasome cascade, and that NALP3 inflammasome inhibition is directly related to BNP deregulatory effect on NF-kB/ERK 1/2 activation.
Our findings reveal a novel potent anti-inflammatory and immunomodulatory role for BNP and open new alleys of investigation for a possible employment of this endogenous agent in the treatment of inflammatory/immune-related and IL-1β/NF-kB/ERK1/2/NALP3/ASC/Caspase-1-associated diseases.
American Psychological Association (APA)
Mezzasoma, Letizia& Antognelli, Cinzia& Talesa, Vincenzo Nicola. 2017. A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kBErk 12 and NALP3ASCCaspase-1 Activation in Human THP-1 Monocyte. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188508
Modern Language Association (MLA)
Mezzasoma, Letizia…[et al.]. A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kBErk 12 and NALP3ASCCaspase-1 Activation in Human THP-1 Monocyte. Mediators of Inflammation No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1188508
American Medical Association (AMA)
Mezzasoma, Letizia& Antognelli, Cinzia& Talesa, Vincenzo Nicola. A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kBErk 12 and NALP3ASCCaspase-1 Activation in Human THP-1 Monocyte. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188508