Andrographolide Activates Keap1Nrf2AREHO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response
Joint Authors
Oh, Won Keun
Seo, Ji Yeon
Pyo, Euisun
An, Jin-Pyo
Kim, Jinwoong
Sung, Sang Hyun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Therapeutic approach of Alzheimer’s disease (AD) has been gradually diversified.
We examined the therapeutic and preventive potential of andrographolide, which is a lactone diterpenoid from Andrographis paniculata, and focused on the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase (HO)-1-inducing effects and the inhibitory activity of amyloid beta (Aβ)42-induced microglial activation related to Nrf2 and nuclear factor κB (NF-κB)-mediated inflammatory responses.
Andrographolide induced the expression and translocation of Nrf2 from the cytoplasm to the nucleus, thereby activating antioxidant response element (ARE) gene transcription and HO-1 expression in murine hippocampal HT22 cells.
Andrographolide eliminated intracellular Aβ42 in BV-2 cells and decreased the production of interleukin (IL)-6, IL-1β, prostaglandin (PG)E2, and nitric oxide (NO) because of artificial phagocytic Aβ42.
It decreased pNF-κB accumulation in the nucleus and the expression of inducible nitric oxide synthase (i-NOS) and cyclooxygenase II (COX-II) in the microglial BV-2 cell line.
In summary, andrographolide activates Nrf2-mediated HO-1 expression and inhibits Aβ42-overexpressed microglial BV-2 cell activation.
These results suggested that andrographolide might have the potential for further examination of the therapeutics of AD.
American Psychological Association (APA)
Seo, Ji Yeon& Pyo, Euisun& An, Jin-Pyo& Kim, Jinwoong& Sung, Sang Hyun& Oh, Won Keun. 2017. Andrographolide Activates Keap1Nrf2AREHO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188510
Modern Language Association (MLA)
Seo, Ji Yeon…[et al.]. Andrographolide Activates Keap1Nrf2AREHO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188510
American Medical Association (AMA)
Seo, Ji Yeon& Pyo, Euisun& An, Jin-Pyo& Kim, Jinwoong& Sung, Sang Hyun& Oh, Won Keun. Andrographolide Activates Keap1Nrf2AREHO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188510