Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA)‎ Study

Abstract EN

Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis.

The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individuals.

The IL-12A and EBI3 polymorphisms were determined in 1162 patients with premature CAD and 873 controls.

Under different models, the EBI3 rs428253 (OR = 0.831, P a d d = 0.036; OR = 0.614, P r e c = 0.033; OR = 0.591, P c o d 2 = 0.027) and IL-12A rs2243115 (OR = 0.674, P a d d = 0.010; OR = 0.676, P d o m = 0.014; OR = 0.698, P h e t = 0.027; OR = 0.694, P c o d 1 = 0.024) polymorphisms were associated with decreased risk of developing premature CAD.

Some polymorphisms were associated with clinical and metabolic parameters.

Significant different levels of IL-35 were observed in EBI3 rs4740 and rs4905 genotypes only in the group of healthy controls.

In summary, our study suggests that the EBI3 and IL-12A polymorphisms play an important role in decreasing the risk of developing premature CAD; it also demonstrates the relationship of the EBI3 rs4740 and rs4905 genotypes with IL-35 levels in healthy individuals.