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Association Study of Tumor Necrosis Factor Receptor 1 (TNFR1) Gene Polymorphisms with Schizophrenia in the Polish Population
Joint Authors
Fila-Daniłow, Anna
Suchanek, Renata
Paul-Samojedny, Monika
Kucia, Krzysztof
Raif, Paweł
Kowalski, Jan
Kowalczyk, Małgorzata
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Schizophrenia is a devastating mental disorder with undetermined aetiology.
Previous research has suggested that dysregulation of proinflammatory cytokines and their receptors plays a role in developing schizophrenia.
We examined the association of the three single nucleotide polymorphisms (SNPs; rs4149576, rs4149577, and rs1860545) in the tumor necrosis factor receptor 1 (TNFR1) gene with the development and psychopathology of paranoid schizophrenia in the Polish Caucasian sample consisting of 388 patients and 657 control subjects.
The psychopathology was assessed using a five-factor model of the Positive and Negative Syndrome Scale (PANSS).
SNPs were genotyped using the TaqMan 5′-exonuclease allelic discrimination assay.
The SNPs tested were not associated with a predisposition to paranoid schizophrenia in either the entire sample or after stratification according to gender.
However, rs4149577 and rs1860545 SNPs were associated with the intensity of the PANSS excitement symptoms in men, which may contribute to the risk of violent behavior.
Polymorphisms in the TNFR1 gene may have an impact on the symptomatology of schizophrenia in men.
American Psychological Association (APA)
Suchanek, Renata& Kucia, Krzysztof& Kowalczyk, Małgorzata& Raif, Paweł& Paul-Samojedny, Monika& Fila-Daniłow, Anna…[et al.]. 2017. Association Study of Tumor Necrosis Factor Receptor 1 (TNFR1) Gene Polymorphisms with Schizophrenia in the Polish Population. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188524
Modern Language Association (MLA)
Suchanek, Renata…[et al.]. Association Study of Tumor Necrosis Factor Receptor 1 (TNFR1) Gene Polymorphisms with Schizophrenia in the Polish Population. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188524
American Medical Association (AMA)
Suchanek, Renata& Kucia, Krzysztof& Kowalczyk, Małgorzata& Raif, Paweł& Paul-Samojedny, Monika& Fila-Daniłow, Anna…[et al.]. Association Study of Tumor Necrosis Factor Receptor 1 (TNFR1) Gene Polymorphisms with Schizophrenia in the Polish Population. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188524