MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression
Joint Authors
Liu, Da
Jia, Aijun
Wang, Yueling
Sun, Wenjin
Xiao, Bing
Wei, Yan
Qiu, Lulu
Mu, Lin
Xu, Li
Li, Jianmin
Zhang, Xiufeng
Peng, Cong
Zhang, Dongshan
Xiang, Xudong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Th17 cells and IL-17 participate in airway neutrophil infiltration characteristics in the pathogenesis of severe asthma.
Methyl-CpG binding domain protein 2 (MBD2) expression increased in CD4+ T cells in peripheral blood samples of asthma patients.
However, little is known about that epigenetic regulation of MBD2 in both immunological pathogenesis of experimental severe asthma and CD4+ T cell differentiation.
Here, we established a neutrophil-predominant severe asthma model, which was characterized by airway hyperresponsiveness (AHR), BALF neutrophil granulocyte (NEU) increase, higher NEU and IL-17 protein levels, and more Th17 cell differentiation.
In the model, MBD2 and IRF4 protein expression increased in the lung and spleen cells.
Under overexpression or silencing of the MBD2 and IRF4 gene, the differentiation of Th17 cells and IL-17 secretion showed positive changes.
IRF4 protein expression showed a positive change with overexpression or silencing of the MBD2 gene, whereas there was no significant difference in the expression of MBD2 under overexpression or silencing of the IRF4 gene.
These data provide novel insights into epigenetic regulation of severe asthma.
American Psychological Association (APA)
Jia, Aijun& Wang, Yueling& Sun, Wenjin& Xiao, Bing& Wei, Yan& Qiu, Lulu…[et al.]. 2017. MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188533
Modern Language Association (MLA)
Jia, Aijun…[et al.]. MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188533
American Medical Association (AMA)
Jia, Aijun& Wang, Yueling& Sun, Wenjin& Xiao, Bing& Wei, Yan& Qiu, Lulu…[et al.]. MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188533