![](/images/graphics-bg.png)
In Vitro Cytotoxicity and Antitumor Activity of Dual-Targeting Drug Delivery System Based on Modified Magnetic Carbon by Folate
Joint Authors
Du, Jinglei
Li, Qiang
Chen, Lin
Wang, Shicai
Zhang, Li
Yu, Shiping
Liu, Xuguang
Yang, Yongzhen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A dual-targeting drug delivery system (DTDDS) with magnetic targeting and active targeting was obtained to improve the targeting and drug-loading capacity of magnetic drug nanocarriers.
An ultraviolet-visible spectrophotometer and flow cytometry were used to investigate the drug-loading and release capacity, cytotoxicity, and inhibition of tumor cell proliferation, separately.
Results show that DTDDS has obvious magnetic characteristics, on which the modification amount of folic acid is 64.82 mg g-1.
Doxorubicin was taken as a template drug to evaluate its drug-loading capacity, which was as high as 577.12 mg g-1.
Good biocompatibility and low cytotoxicity of DTDDS were further confirmed.
Moreover, DTDDS can target the folate receptor on the surface of HeLa cells and deliver doxorubicin into HeLa cells, thereby increasing the proliferation inhibition for cancer cells.
Therefore, this new dual-targeting drug delivery system shows potential in significantly reducing the toxic side effects of chemotherapy and improving chemotherapy efficiency.
American Psychological Association (APA)
Du, Jinglei& Li, Qiang& Chen, Lin& Wang, Shicai& Zhang, Li& Yu, Shiping…[et al.]. 2020. In Vitro Cytotoxicity and Antitumor Activity of Dual-Targeting Drug Delivery System Based on Modified Magnetic Carbon by Folate. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188535
Modern Language Association (MLA)
Du, Jinglei…[et al.]. In Vitro Cytotoxicity and Antitumor Activity of Dual-Targeting Drug Delivery System Based on Modified Magnetic Carbon by Folate. Journal of Nanomaterials No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1188535
American Medical Association (AMA)
Du, Jinglei& Li, Qiang& Chen, Lin& Wang, Shicai& Zhang, Li& Yu, Shiping…[et al.]. In Vitro Cytotoxicity and Antitumor Activity of Dual-Targeting Drug Delivery System Based on Modified Magnetic Carbon by Folate. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188535