Preparation of Cholesteryl-Modified Aminated Pullulan Nanoparticles to Evaluate Nanoparticle of Hydrophobic Degree on Drug Release and Cytotoxicity
Joint Authors
Tao, Xiao-Jun
Zhong, Wu
Nie, Yu
Wang, Rong
Yuan, Huabing
Zhou, Ping
Hu, Wei
Yang, Ping
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The formation of nanoparticles (NPs) and surface properties such as size and charge are affected by the amphiphilic property of polymer, which is vital for evaluating their function.
Here, we synthesized cholesteryl-modified aminated pullulan polymers (CHPNs) with different amounts of cholesterol succinate (CHS).
We characterized the three hydrophobically modified polymers (CHPN1, CHPN2, and CHPN3) (CHS: Pu‐NH2=1/5,2/5,3/5) by Fourier transform infrared spectrometry.
Dynamic light scattering (DLS) was used to measure particle size and zeta potential of CHPN NPs.
The particle sizes of the three NPs CHPN1, CHPN2, and CHPN3 were 178.0, 144.4, and 97.8 nm, respectively.
The particle size was related to the cholesteryl substitution of polymers to a certain extent: the stronger the hydrophobicity, the smaller the particle size.
In 48 h, the drug release for CHPN3 and CHPN1 NPs was 57.8% and 72.7%.
Thus, the NPs showed good sustained drug release: the greater the degree of hydrophobic substitution, the better the sustained release.
The cytotoxicity findings were reversed: CHPN1 NPs, with low hydrophobic substitution, showed the best inhibition of Lewis lung cancer cells.
American Psychological Association (APA)
Yuan, Huabing& Zhong, Wu& Wang, Rong& Zhou, Ping& Nie, Yu& Hu, Wei…[et al.]. 2020. Preparation of Cholesteryl-Modified Aminated Pullulan Nanoparticles to Evaluate Nanoparticle of Hydrophobic Degree on Drug Release and Cytotoxicity. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1188540
Modern Language Association (MLA)
Yuan, Huabing…[et al.]. Preparation of Cholesteryl-Modified Aminated Pullulan Nanoparticles to Evaluate Nanoparticle of Hydrophobic Degree on Drug Release and Cytotoxicity. Journal of Nanomaterials No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1188540
American Medical Association (AMA)
Yuan, Huabing& Zhong, Wu& Wang, Rong& Zhou, Ping& Nie, Yu& Hu, Wei…[et al.]. Preparation of Cholesteryl-Modified Aminated Pullulan Nanoparticles to Evaluate Nanoparticle of Hydrophobic Degree on Drug Release and Cytotoxicity. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1188540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188540