5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice
Joint Authors
Bi, Jianbin
Zhang, Jingyao
Liu, Sushun
Pang, Qing
Zhang, Ruiyao
Wang, Shun
Liu, Chang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection with a high mortality.
5-Hydroxytryptamine (5-HT) is an important regulatory factor in inflammation.
The aim of this study is to investigate the role of 5-HT on cecal ligation and puncture- (CLP-) induced sepsis in the mouse model.
CLP was performed on C57B/6 wild-type (WT) mice and tryptophan hydroxylase 1 (TPH1) knockout (KO) mice.
The results showed that the 5-HT-sufficient group mice had a significantly lower survival rate than the 5-HT-deficient group in CLP-induced sepsis and septic shock.
The KO-CLP sepsis group received a lower clinical score than the WT-CLP sepsis group.
Meanwhile, the body temperature of mice in the KO-CLP sepsis group was higher than that in the WT-CLP sepsis group and was much closer to the normal body temperature 24 hours after CLP.
The tissue histopathology analysis revealed that 5-HT markedly exacerbated histological damages in the peritoneum, lung, liver, kidney, intestinal tissue, and heart in sepsis.
Moreover, significant lower levels of TNF-α, IL-6, bacterial loads, MPO, and ROS were discovered in the KO-CLP sepsis group in contrast to the WT-CLP sepsis group.
In conclusion, 5-HT drives mortality and exacerbates organ dysfunction by promoting serum cytokines and bacterial loads as well as facilitating oxidative stress in the process of sepsis.
American Psychological Association (APA)
Zhang, Jingyao& Bi, Jianbin& Liu, Sushun& Pang, Qing& Zhang, Ruiyao& Wang, Shun…[et al.]. 2017. 5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188541
Modern Language Association (MLA)
Zhang, Jingyao…[et al.]. 5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188541
American Medical Association (AMA)
Zhang, Jingyao& Bi, Jianbin& Liu, Sushun& Pang, Qing& Zhang, Ruiyao& Wang, Shun…[et al.]. 5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188541