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Association between Interleukin-10-1082 GA and Tumor Necrosis Factor-α 308 GA Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants
Joint Authors
Kheiri, Soleiman
Khoshdel, Abolfazl
Omidvari, Peyman
Moradi, Fahimeh
Hamidi, Majid
Teimori, Hossein
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome.
The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene polymorphisms and their association with the risk of RDS in preterm infants.
One-hundred and nineteen patients with RDS and 119 healthy preterm infants were enrolled.
PCR restriction fragment length polymorphism was used to determine the frequency of IL-10 and TNF-α genotypes at -1082 A and -308 A, respectively.
One-hundred and nineteen out of 238 infants had RDS (50%).
The age of the mothers and gestational age ranged 17–45 (mean: 28.6±5.3) years and 24–34 (mean: 34.3±2.38) weeks, respectively.
Totally, 23 deaths were recorded in the RDS group.
Incidence of TNF-α-308 A/A and TNF-α-308 G/A was 84% and 16%, respectively.
TNF-a-308 G/G was not found in both groups.
Prevalence of IL-10-1082 G/G and IL-10-1082 G/A variants was 65.5% and 34.5%, respectively.
IL-10-1082 A/A was not found in both groups.
The incidence of the allele G in the IL-10-1082 polymorphism was lower in RDS group (P<0.05).
We found that the risk of RDS was correlated to sex, gestational age, and IL-10-1082.
American Psychological Association (APA)
Khoshdel, Abolfazl& Kheiri, Soleiman& Omidvari, Peyman& Moradi, Fahimeh& Hamidi, Majid& Teimori, Hossein. 2017. Association between Interleukin-10-1082 GA and Tumor Necrosis Factor-α 308 GA Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188544
Modern Language Association (MLA)
Khoshdel, Abolfazl…[et al.]. Association between Interleukin-10-1082 GA and Tumor Necrosis Factor-α 308 GA Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188544
American Medical Association (AMA)
Khoshdel, Abolfazl& Kheiri, Soleiman& Omidvari, Peyman& Moradi, Fahimeh& Hamidi, Majid& Teimori, Hossein. Association between Interleukin-10-1082 GA and Tumor Necrosis Factor-α 308 GA Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188544