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Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking
Joint Authors
Zhou, Wei-Xun
Gong, Haihong
Liu, Tao
Chen, Wei
Gao, Jinming
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-29
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Background.
IRAK-M, negatively regulating Toll-like receptor, is shown the dual properties in the varied disease contexts.
We studied the effect of IRAK-M deficiency on cigarette smoking- (CS-) induced airway inflammation under acute or subacute conditions in a mouse model.
Methods.
A number of cellular and molecular techniques were used to detect the differences between IRAK-M knockout (KO) and wild type (WT) mice exposed to 3-day or 7-week CS.
Results.
Airway inflammation was comparable between IRAK-M KO and WT mice under 3-day CS exposure.
Upon short-term CS exposure and lipopolysaccharide (LPS) inhalation, IRAK-M KO mice demonstrated worse airway inflammation, significantly higher percentage of Th17 cells and concentrations of proinflammatory cytokines in the lungs, and significantly elevated expression of costimulatory molecules CD40 and CD86 by lung dendritic cells (DCs) or macrophages.
Conversely, 7-week CS exposed IRAK-M KO mice demonstrated significantly attenuated airway inflammation, significantly lower concentrations of proinflammatory cytokines in the lungs, significantly increased percentage of Tregs, and lower expression of CD11b and CD86 by lung DCs or macrophages.
Conclusions.
IRAK-M plays distinctive effect on CS-induced airway inflammation, and influences Treg/Th17 balance and expression of costimulatory molecules by DCs and macrophages, depending on duration and intensity of stimulus.
American Psychological Association (APA)
Gong, Haihong& Liu, Tao& Chen, Wei& Zhou, Wei-Xun& Gao, Jinming. 2017. Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1188549
Modern Language Association (MLA)
Gong, Haihong…[et al.]. Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking. Mediators of Inflammation No. 2017 (2017), pp.1-20.
https://search.emarefa.net/detail/BIM-1188549
American Medical Association (AMA)
Gong, Haihong& Liu, Tao& Chen, Wei& Zhou, Wei-Xun& Gao, Jinming. Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1188549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188549