Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis
Joint Authors
Vinícius da Silva, Marcos
de Oliveira, Carlo Jose Freire
Sales-Campos, Helioswilton
Coutinho de Sousa, Beatriz
da Costa, Thiago Alvares
Lazo-Chica, Javier Emilio
Degasperi, Thatiane do Prado
Rodrigues Junior, Virmondes
Uber Bucek, Elizabeth
Machado, Juliana Reis
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Morinda citrifolia L.
(noni) has been shown to treat different disorders.
However, data concerning its role in the treatment of intestinal inflammation still require clarification.
In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days.
NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss.
Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate.
Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-α and IFN-γ, was also observed in the intestine.
Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates.
Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening.
These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease.
American Psychological Association (APA)
Coutinho de Sousa, Beatriz& Machado, Juliana Reis& Vinícius da Silva, Marcos& da Costa, Thiago Alvares& Lazo-Chica, Javier Emilio& Degasperi, Thatiane do Prado…[et al.]. 2017. Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188560
Modern Language Association (MLA)
Coutinho de Sousa, Beatriz…[et al.]. Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188560
American Medical Association (AMA)
Coutinho de Sousa, Beatriz& Machado, Juliana Reis& Vinícius da Silva, Marcos& da Costa, Thiago Alvares& Lazo-Chica, Javier Emilio& Degasperi, Thatiane do Prado…[et al.]. Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188560