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In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars
Joint Authors
Vinícius da Silva, Marcos
dos Reis, Marlene Antônia
Peixoto, Alberto Borges
Silva, Isabela Rios da
Tiveron, Luciana Colombo Rodrigues da Cunha
Carneiro, Carla Aparecida Xavier
Furtado, Pedro Carvalho
Rodrigues, Bárbara Rocha
Rodrigues, Denise Bertulucci Rocha
Rodrigues, Virmondes
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation.
The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group.
Results showed that there was a predominance of women and nonwhite and direct black ancestry.
Keloid showed a significant increase in total and type III collagen.
Significantly, the expression of mRNA for TGF-β in keloid was increased, the expressions of IFN-γ, IFN-γR1, and IL-10 were lower, and IFN-γR1 and TNF-α had no statistical difference.
Correlations between collagen type III and TGF-β mRNA expression were positive and significant, IFN-γ, IFN-γR1, and IL-10 were negative and significant, and TNF-α showed no statistical difference.
We conclude that there was a significant increase of total collagen in keloid and predominance of collagen type III compared to the controls, showing keloid as an immature lesion.
There is a significant increase in TGF-β mRNA in keloid lesions, and a significant decrease in IFN-γ and IL-10, suggesting that these cytokines are related to keloid lesions.
American Psychological Association (APA)
Silva, Isabela Rios da& Tiveron, Luciana Colombo Rodrigues da Cunha& Vinícius da Silva, Marcos& Peixoto, Alberto Borges& Carneiro, Carla Aparecida Xavier& dos Reis, Marlene Antônia…[et al.]. 2017. In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188563
Modern Language Association (MLA)
Silva, Isabela Rios da…[et al.]. In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188563
American Medical Association (AMA)
Silva, Isabela Rios da& Tiveron, Luciana Colombo Rodrigues da Cunha& Vinícius da Silva, Marcos& Peixoto, Alberto Borges& Carneiro, Carla Aparecida Xavier& dos Reis, Marlene Antônia…[et al.]. In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188563