![](/images/graphics-bg.png)
Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293TLR4 Cell Line
Joint Authors
Xiao, Zhihui
Wu, Wenjun
Poltoratsky, Vladimir
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chronic inflammation is associated with cancer.
CXCL8 promotes tumor microenvironment construction through recruiting leukocytes and endothelial progenitor cells that are involved in angiogenesis.
It also enhances tumor cell proliferation and migration.
Metformin, type II diabetes medication, demonstrates anticancer properties via suppressing inflammation, tumor cell proliferation, angiogenesis, and metastasis.
This study intended to address the role of metformin in regulation of CXCL8 expression and cell proliferation and migration.
Our data indicated that metformin suppressed LPS-induced CXCL8 expression in a dose-dependent manner through inhibiting NF-κB, but not AP-1 and C/EBP, activities under the conditions we used.
This inhibitory effect of metformin is achieved through dampening LPS-induced NF-κB nuclear translocation.
Cell migration was inhibited by metformin under high dose (10 mM), but not cell proliferation.
American Psychological Association (APA)
Xiao, Zhihui& Wu, Wenjun& Poltoratsky, Vladimir. 2017. Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293TLR4 Cell Line. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188566
Modern Language Association (MLA)
Xiao, Zhihui…[et al.]. Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293TLR4 Cell Line. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188566
American Medical Association (AMA)
Xiao, Zhihui& Wu, Wenjun& Poltoratsky, Vladimir. Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293TLR4 Cell Line. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188566