Expression of the JAKSTAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis
Joint Authors
Wieczfinska, Joanna
Waszczykowska, Elżbieta
Woźniacka, Anna
Żebrowska, Agnieszka
Juczynska, K.
Marian, Danilewicz
Pawliczak, Rafal
Wagrowska-Danilewicz, Malgorzata
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes.
Irregular functioning of the cascade may contribute to pathogenesis of autoimmune diseases; however, there are no reports concerning autoimmune bullous diseases yet to be published.
The aim of this study was to evaluate the expression of proteins constituting the JAK/STAT signaling pathway in skin lesions and perilesional area in dermatitis herpetiformis (DH) and bullous pemphigoid (BP), as well as in the control group.
Skin biopsies were collected from 21 DH patients, from 20 BP patients, and from 10 healthy volunteers.
The localization and expression of selected STAT and JAK proteins were examined by immunohistochemistry and immunoblotting.
We found significantly higher expression of JAK/STAT proteins in skin lesions in patients with BP and DH, in comparison to perilesional skin and the control group, which may be related to proinflammatory cytokine network and induction of inflammatory infiltrate in tissues.
Our findings suggest that differences in the JAK and STAT expression may be related to distinct cytokines activating them and mediating neutrophilic and/or eosinophilic infiltrate.
American Psychological Association (APA)
Juczynska, K.& Woźniacka, Anna& Waszczykowska, Elżbieta& Marian, Danilewicz& Wagrowska-Danilewicz, Malgorzata& Wieczfinska, Joanna…[et al.]. 2017. Expression of the JAKSTAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188571
Modern Language Association (MLA)
Juczynska, K.…[et al.]. Expression of the JAKSTAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188571
American Medical Association (AMA)
Juczynska, K.& Woźniacka, Anna& Waszczykowska, Elżbieta& Marian, Danilewicz& Wagrowska-Danilewicz, Malgorzata& Wieczfinska, Joanna…[et al.]. Expression of the JAKSTAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188571