Evaluation of the Cytotoxic Effect of Rutin Prenanoemulsion in Lung and Colon Cancer Cell Lines
Joint Authors
Hoai, Tran Thanh
Yen, Phan Thi
Dao, Tran Thi Bich
Long, Luu Hai
Anh, Duong Xuan
Minh, Luu Hai
Anh, Bui Quoc
Thuong, Nghiem Thi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In this work, prenanoemulsion of rutin was prepared using PEG and Tween as emulsifiers via homogenization and evaporation techniques.
The particle size of rutin was investigated with high-resolution transmission electron microscopy (HR-TEM); particle size distribution and its chemical structure were analysed by nuclear magnetic resonance (NMR) and Fourier transformed infrared (FT-IR) spectroscopy.
It was found that rutin in the prenanoemulsion has excellent solubility in water with the size approximately 15 nm.
The chemical structure of nanorutin in prenanoemulsion was identical to that of the pure rutin.
It suggested that there is no chemical modification of rutin in the prenanoemulsion.
From high-performance liquid chromatography (HPLC), the amount of rutin in the prenanoemulsion was determined to be 9.27%.
The cytotoxic effect of rutin in the preemulsion was investigated via in vitro tests to determine rutin’s efficacy in A549 lung cancer cell and colon cancer cell treatment.
The results demonstrated that rutin in the prenanoemulsion could inhibit A549 lung cancer cells and colon cancer cells efficiently.
American Psychological Association (APA)
Hoai, Tran Thanh& Yen, Phan Thi& Dao, Tran Thi Bich& Long, Luu Hai& Anh, Duong Xuan& Minh, Luu Hai…[et al.]. 2020. Evaluation of the Cytotoxic Effect of Rutin Prenanoemulsion in Lung and Colon Cancer Cell Lines. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188599
Modern Language Association (MLA)
Hoai, Tran Thanh…[et al.]. Evaluation of the Cytotoxic Effect of Rutin Prenanoemulsion in Lung and Colon Cancer Cell Lines. Journal of Nanomaterials No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1188599
American Medical Association (AMA)
Hoai, Tran Thanh& Yen, Phan Thi& Dao, Tran Thi Bich& Long, Luu Hai& Anh, Duong Xuan& Minh, Luu Hai…[et al.]. Evaluation of the Cytotoxic Effect of Rutin Prenanoemulsion in Lung and Colon Cancer Cell Lines. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188599