Development of Itraconazole-Loaded Polymeric Nanoparticle Dermal Gel for Enhanced Antifungal Efficacy
Joint Authors
Ho, Hoang Nhan
Le, Thien Giap
Dao, Thi Thanh Tuyen
Le, Thi Ha
Dinh, Thi Thanh Hai
Nguyen, Dang Hoa
Tran, Trinh Cong
Nguyen, Chien Ngoc
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fungal infection of the skin is one of the most common dermatological diseases in the world.
Gel formulations are among the most suitable dosage forms for topical use to treat cutaneous infection.
Nanotechnology is a promising approach to penetrate the deeper skin layers and enhance permeability of itraconazole (ITZ) through the stratum corneum.
ITZ-loaded nanoparticles (ITZ NPs) were fabricated using the evaporation emulsion method, followed by incorporation of NPs into gel using Carbopol 934 as the gel-forming excipient.
The physical properties, in vitro release, ex vivo permeation studies, and antifungal activity of ITZ NP gel were characterized.
ITZ NPs were almost spherical in shape with colloidal sizes in the range of 200 nm.
The drug encapsulation efficiency was 98.79±1.24%.
ITZ NP gel demonstrated a sustained ex vivo permeation of ITZ over 24 h through excised rat skin and a higher drug penetrating capacity than that of a gel containing ITZ-saturated suspension.
The in vitro antifungal activity of the ITZ-loaded NP incorporated gel was better than that of ITZ dispersion.
Incorporation of the ITZ-loaded nanosystem into gel has the potential to enhance antifungal activity through transdermal drug delivery.
American Psychological Association (APA)
Ho, Hoang Nhan& Le, Thien Giap& Dao, Thi Thanh Tuyen& Le, Thi Ha& Dinh, Thi Thanh Hai& Nguyen, Dang Hoa…[et al.]. 2020. Development of Itraconazole-Loaded Polymeric Nanoparticle Dermal Gel for Enhanced Antifungal Efficacy. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188604
Modern Language Association (MLA)
Ho, Hoang Nhan…[et al.]. Development of Itraconazole-Loaded Polymeric Nanoparticle Dermal Gel for Enhanced Antifungal Efficacy. Journal of Nanomaterials No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1188604
American Medical Association (AMA)
Ho, Hoang Nhan& Le, Thien Giap& Dao, Thi Thanh Tuyen& Le, Thi Ha& Dinh, Thi Thanh Hai& Nguyen, Dang Hoa…[et al.]. Development of Itraconazole-Loaded Polymeric Nanoparticle Dermal Gel for Enhanced Antifungal Efficacy. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188604