Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say
Joint Authors
Saba, Evelyn
Kwon, Hyuk-Woo
Irfan, Muhammad
Lee, Yuan Yee
Shafeeq, Tahir
Seo, Myung Gi
Lee, Kyeong-Yeoll
Park, Sang-Joon
Rhee, Man Hee
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Pest control in the agricultural fields, a major concern globally, is currently achieved through chemical or biological methods.
Chemical methods, which leave toxic residue in the produce, are less preferred than biological methods.
Venoms injected by stings of various wasps that kill the pest is considered as the examples of the biological method.
Although several studies have investigated the biological control of pests through these venoms, very few studies have reported the effects of these venoms on mammalian cells.
Bracon hebetor, an ectoparasitoid of the order Hymenoptera, is having a paramount importance in parasitizing various lepidopterous larvae including Plodia interpunctella also called as Indianmeal moth (IMM).
Since it is biologically controlled by B.
hebetor venom, therefore in our study, herein for the first time, we report the anti-inflammatory activities of the venom from B.
hebetor (BHV).
We developed a septic shock mice model for in vivo anti-inflammatory studies and RAW 264.7 cells for in vitro studies.
Our results clearly demonstrate that BHV can dose dependently abrogate the nitric oxide (NO) production and suppress the levels of proinflammatory mediators and cytokines without posing any cytotoxicity via the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.
American Psychological Association (APA)
Saba, Evelyn& Shafeeq, Tahir& Irfan, Muhammad& Lee, Yuan Yee& Kwon, Hyuk-Woo& Seo, Myung Gi…[et al.]. 2017. Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188630
Modern Language Association (MLA)
Saba, Evelyn…[et al.]. Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188630
American Medical Association (AMA)
Saba, Evelyn& Shafeeq, Tahir& Irfan, Muhammad& Lee, Yuan Yee& Kwon, Hyuk-Woo& Seo, Myung Gi…[et al.]. Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188630