A Novel CD48-Based Analysis of Sepsis-Induced Mouse Myeloid-Derived Suppressor Cell Compartments
Joint Authors
Kong, Yaxian
Zeng, Hui
Jia, Bei
Zhao, Chenchen
Li, Guoli
Ma, Yaluan
Wang, Qiuping
Wang, Beibei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous subset of cells that expands dramatically in many disease states and can suppress T-cell responses.
MDSCs mainly include monocytic and granulocytic subpopulations that can be distinguished in mice by the expression of Ly6G and Ly6C cell surface markers.
This identification system has been validated in experimental tumor models, but not in models of inflammation-associated conditions such as sepsis.
We challenged growth factor independent 1 transcription repressor green fluorescent protein (Gfi1:GFP) knock-in reporter mice with cecal ligation and puncture surgery and found that CD11b+Ly6GlowLy6Chigh MDSCs in this sepsis model comprised both monocytic and granulocytic MDSCs.
The evidence that conventional Ly6G/Ly6C marker analysis may not be suited to study of inflammation-induced MDSCs led to the development of a novel strategy of distinguishing granulocytic MDSCs from monocytic MDSCs in septic mice by expression of CD48.
Application of this novel model should help achieve a more accurate understanding of the inflammation-induced MDSC activity.
American Psychological Association (APA)
Jia, Bei& Zhao, Chenchen& Li, Guoli& Kong, Yaxian& Ma, Yaluan& Wang, Qiuping…[et al.]. 2017. A Novel CD48-Based Analysis of Sepsis-Induced Mouse Myeloid-Derived Suppressor Cell Compartments. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188675
Modern Language Association (MLA)
Jia, Bei…[et al.]. A Novel CD48-Based Analysis of Sepsis-Induced Mouse Myeloid-Derived Suppressor Cell Compartments. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188675
American Medical Association (AMA)
Jia, Bei& Zhao, Chenchen& Li, Guoli& Kong, Yaxian& Ma, Yaluan& Wang, Qiuping…[et al.]. A Novel CD48-Based Analysis of Sepsis-Induced Mouse Myeloid-Derived Suppressor Cell Compartments. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188675