Osteopontin Impacts West Nile virus Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points

Joint Authors

Marcondes, Maria Cecilia Garibaldi
Fox, Howard
Flynn, Claudia
Conti, Bruno
Bortell, Nikki

Source

Mediators of Inflammation

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-07-25

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

Osteopontin (OPN) is a molecule that is common in central nervous system (CNS) pathologies, which participates in the activation, migration, and survival of inflammatory cells.

However, the mechanisms by which OPN modulates inflammatory pathways are not clear.

To understand the role of OPN in CNS viral infections, we used a lethal mouse model of West Nile virus (WNV), characterized by the injection of high doses of the Eg101 strain of WNV, causing the increase of OPN levels in the brain since early time points.

To measure the impact of OPN in neuropathogenesis and resistance, we compared C57BI/6 WT with mice lacking the OPN gene (OPN KO).

OPN KO presented a significantly higher mortality compared to WT mice, detectable since day 5 pi.

Our data suggests that OPN expression at early time points may provide protection against viral spread in the CNS by negatively controlling the type I IFN-sensitive, caspase 1-dependent inflammasome, while promoting an alternative caspase 8-associated pathway, to control the apoptosis of infected cells during WNV infection in the CNS.

Overall, we conclude that the expression of OPN maintains a critical threshold in the innate immune response that controls apoptosis and lethal viral spread in early CNS infection.

American Psychological Association (APA)

Bortell, Nikki& Flynn, Claudia& Conti, Bruno& Fox, Howard& Marcondes, Maria Cecilia Garibaldi. 2017. Osteopontin Impacts West Nile virus Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188683

Modern Language Association (MLA)

Bortell, Nikki…[et al.]. Osteopontin Impacts West Nile virus Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188683

American Medical Association (AMA)

Bortell, Nikki& Flynn, Claudia& Conti, Bruno& Fox, Howard& Marcondes, Maria Cecilia Garibaldi. Osteopontin Impacts West Nile virus Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188683

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1188683