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Higher-Order Chromatin Regulation of Inflammatory Gene Expression
Joint Authors
Xu, Jin-Wen
Liu, Jun
Ling, Shuang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Whether it is caused by viruses and bacteria infection, or low-grade chronic inflammation of atherosclerosis and cellular senescence, the transcription factor (TF) NF-κB plays a central role in the inducible expression of inflammatory genes.
Accumulated evidence has indicated that the chromatin environment is the main determinant of TF binding in gene expression regulation, including the stimulus-responsive NF-κB.
Dynamic changes in intra- and interchromosomes are the key regulatory mechanisms promoting the binding of TFs.
When an inflammatory process is triggered, NF-κB binds to enhancers or superenhancers, triggering the transcription of enhancer RNA (eRNA), driving the chromatin of the NF-κB-binding gene locus to construct transcriptional factories, and forming intra- or interchromosomal contacts.
These processes reveal a mechanism in which intrachromosomal contacts appear to be cis-control enhancer-promoter communications, whereas interchromosomal regulatory elements construct trans-form relationships with genes on other chromosomes.
This article will review emerging evidence on the genome organization hierarchy underlying the inflammatory response.
American Psychological Association (APA)
Xu, Jin-Wen& Ling, Shuang& Liu, Jun. 2017. Higher-Order Chromatin Regulation of Inflammatory Gene Expression. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1188707
Modern Language Association (MLA)
Xu, Jin-Wen…[et al.]. Higher-Order Chromatin Regulation of Inflammatory Gene Expression. Mediators of Inflammation No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1188707
American Medical Association (AMA)
Xu, Jin-Wen& Ling, Shuang& Liu, Jun. Higher-Order Chromatin Regulation of Inflammatory Gene Expression. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1188707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188707