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The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine
Joint Authors
Peruzzi, Mariangela
Sciarretta, Sebastiano
Frati, G.
Cavarretta, Elena
Forte, Maurizio
Schirone, Leonardo
Dal Sasso, Eleonora
Palmerio, Silvia
Gerosa, Gino
Iop, Laura
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population.
During aging, the progressive impairment of the cardiovascular functions results from the compromised tissue abilities to protect the heart against stress.
At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells.
Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis.
In this review, we explore the intrinsic and extrinsic causes of cellular senescence and their role in the onset of these cardiovascular pathologies.
Additionally, we dissect the effects of aging on the cardiac endogenous and exogenous reservoirs of stem cells.
Finally, we offer an overview on the strategies of regenerative medicine that have been advanced in the quest for heart rejuvenation.
American Psychological Association (APA)
Iop, Laura& Dal Sasso, Eleonora& Schirone, Leonardo& Forte, Maurizio& Peruzzi, Mariangela& Cavarretta, Elena…[et al.]. 2017. The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188712
Modern Language Association (MLA)
Iop, Laura…[et al.]. The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine. Mediators of Inflammation No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1188712
American Medical Association (AMA)
Iop, Laura& Dal Sasso, Eleonora& Schirone, Leonardo& Forte, Maurizio& Peruzzi, Mariangela& Cavarretta, Elena…[et al.]. The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188712