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The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia
Joint Authors
Toldi, Gergely
Bajnok, Anna
Ivanova, Maria
Rigó, János
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia.
Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, the results are controversial and a comprehensive analysis of activation markers is lacking.
The characteristics of cellular adhesion molecules in preeclampsia are yet to be described.
Material and Methods.
Peripheral blood samples of 18 preeclamptic patients and 20 healthy pregnant women in the third trimester were evaluated using flow cytometry to characterize the cell surface expression of T lymphocyte activation markers and selectins.
Results.
We found an elevated ratio of HLA-DR and CD122-, CD62E-, and CD62L-expressing cells among the CD4+ T lymphocytes in PE in comparison to healthy pregnancy.
No alterations were found in the prevalence of CD69-, CD25-, and CD62P-expressing lymphocytes and CD11c-expressing monocytes.
Conclusions.
Our findings support the role of activated T lymphocytes and specific cell adhesion molecules in the pathogenesis of preeclampsia.
American Psychological Association (APA)
Bajnok, Anna& Ivanova, Maria& Rigó, János& Toldi, Gergely. 2017. The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188719
Modern Language Association (MLA)
Bajnok, Anna…[et al.]. The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia. Mediators of Inflammation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1188719
American Medical Association (AMA)
Bajnok, Anna& Ivanova, Maria& Rigó, János& Toldi, Gergely. The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188719