Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status

Joint Authors

Casella, Claudio
Mazzaferro, Sandro
Galani, Alessandro
Lai, Silvia
Mitterhofer, Anna Paola
Tinti, Francesca
Bonci, Enea
Giovannetti, Antonello
Perrotta, Adolfo Marco
Bagordo, Domenico
Murciano, Manuel
Celani, Camilla
Troiani, Patrizia
Cimino, Giuseppe
Palange, Paolo

Source

Journal of Nutrition and Metabolism

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-30

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Nutrition & Dietetics

Abstract EN

Background.

Cystic fibrosis (CF) is one of the most frequent genetic diseases.

The discovery and implementation of new therapies prolonged the survival of CF patients in the last years.

Evaluation of long-term complications could be useful to improve the outcome of these patients.

Aim of the Study.

To evaluate renal function, metabolic, nutritional, and inflammatory status in CF patients on cystic fibrosis transmembrane regulator (CFTR) modulators therapy as well as lung transplant recipients (LRs) and patients on conservative therapy (control group).

Materials and Methods.

We performed a prospective, longitudinal study on 69 CF patients.

Clinical and laboratory parameters (metabolic and nutritional indices and inflammatory markers) were evaluated in all patients before starting CFTR therapy or transplant (T0) and after 3 years (T1).

Results.

We enrolled 69 CF patients (42 males).

Patients were distributed into three groups.

The average age was 35.01 ± 10.57 years for the control group (group 0), 32.47 ± 9.40 years for patients on CFTR modulators therapy (group 1), and 38.93 ± 7.14 years for LRs (group 2).

At T1, we showed a significant difference among the three groups in terms of renal function indices: creatinine, eGFR, serum nitrogen as well as serum uric acid, sodium, and potassium (p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, and p<0.001, respectively), particularly in LRs patients.

Significant differences were found in nutritional status parameters among the three groups: total protein, serum albumin, serum fibrinogen, serum transferrin, and white blood cell counts (p<0.001, p=0.037, p=0.04, p=0.003, and p=0.007, respectively), particularly in LRs compared with other groups.

Moreover, we found significant differences in metabolic profile (HbA1c, p=0.026) and inflammatory status, with a significant difference in C-reactive protein values, neutrophil counts, and neutrophil-lymphocyte ratio (NLR) among the three groups (p<0.001, p=0.005, and p=0.026, respectively).

Conclusions.

Our study showed a reduced renal function and poor nutritional status in LRs, along with worse metabolic control.

Moreover, we showed a lower inflammatory status in patients on CFTR modulators therapy.

Therefore, we suggest early and careful monitoring of renal function, metabolic, and nutritional parameters in CF patients, whether they are on conservative therapy, CFTR modulators therapy, and LRs patients.

American Psychological Association (APA)

Lai, Silvia& Mazzaferro, Sandro& Mitterhofer, Anna Paola& Tinti, Francesca& Casella, Claudio& Galani, Alessandro…[et al.]. 2020. Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status. Journal of Nutrition and Metabolism،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188720

Modern Language Association (MLA)

Casella, Claudio…[et al.]. Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status. Journal of Nutrition and Metabolism No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1188720

American Medical Association (AMA)

Lai, Silvia& Mazzaferro, Sandro& Mitterhofer, Anna Paola& Tinti, Francesca& Casella, Claudio& Galani, Alessandro…[et al.]. Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status. Journal of Nutrition and Metabolism. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188720

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1188720