Ex Vivo Study of Laban's Role in Decreasing Hemolysis Crisis in G6PD-Deficient Patients

Joint Authors

Zam, Wissam
Belal, Loay

Source

Journal of Nutrition and Metabolism

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-01-21

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Nutrition & Dietetics

Abstract EN

In spite of the vast nutritional and environmental benefits provided by fava bean (Vicia faba), the ingestion of vicine/convicine provokes an acute hemolytic anemia called favism in individuals with a glucose-6-phosphate dehydrogenase (G6PD) deficiency.

The elimination of these glycosides is a goal that could be accomplished using different processing methods including bacteriological treatment.

Laban as a good source of lactic acid bacteria was tested in an ex vivo assay on human blood samples in order to determine its capacity in decreasing the hemolysis crisis induced by the ingestion of fava beans.

Results indicate a significant decrease in human blood cell hemolysis after the treatment of fava beans by Laban.

This decrease in hemolysis was also correlated with the G6PD deficiency categorization.

The highest hemolysis level (mean: 23.11 ± 0.76%) was observed in samples with G6PD activity between 10 and 30%, while the lowest hemolysis level (mean: 5.75 ± 0.64%) was observed in samples with G6PD activity more than 60%.

This decrease was correlated with a high antioxidant capacity of Laban (51.61 ± 1.13% expressed by the percentage inhibition of DPPH radical).

The counts of isolates from MRS and M17 culture plates were 6.75 ± 0.095 and 7.91 ± 0.061 log cfu ml–1, respectively.

In conclusion, the synergy between the antioxidant properties of Laban and the possible decrease of vicine and convicine concentrations by lactobacillus found in the fermented dairy products could explain the ability of Laban to reduce the hemolysis crisis ex vivo.

American Psychological Association (APA)

Zam, Wissam& Belal, Loay. 2020. Ex Vivo Study of Laban's Role in Decreasing Hemolysis Crisis in G6PD-Deficient Patients. Journal of Nutrition and Metabolism،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1188741

Modern Language Association (MLA)

Zam, Wissam& Belal, Loay. Ex Vivo Study of Laban's Role in Decreasing Hemolysis Crisis in G6PD-Deficient Patients. Journal of Nutrition and Metabolism No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1188741

American Medical Association (AMA)

Zam, Wissam& Belal, Loay. Ex Vivo Study of Laban's Role in Decreasing Hemolysis Crisis in G6PD-Deficient Patients. Journal of Nutrition and Metabolism. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1188741

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1188741