The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications
Joint Authors
Nobili, Valerio
de Oliveira, Felipe Leite
Gaudio, Eugenio
Alisi, Anna
Panera, Nadia
Carpino, Guido
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The obese phenotype is characterized by a state of chronic low-grade systemic inflammation that contributes to the development of comorbidities, including nonalcoholic fatty liver disease (NAFLD).
In fact, NAFLD is often associated with adipocyte enlargement and consequent macrophage recruitment and inflammation.
Macrophage polarization is often associated with the proinflammatory state in adipose tissue.
In particular, an increase of M1 macrophages number or of M1/M2 ratio triggers the production and secretion of various proinflammatory signals (i.e., adipocytokines).
Next, these inflammatory factors may reach the liver leading to local M1/M2 macrophage polarization and consequent onset of the histological damage characteristic of NAFLD.
Thus, the role of macrophage polarization and inflammatory signals appears to be central for pathogenesis and progression of NAFLD, even if the heterogeneity of macrophages and molecular mechanisms that govern their phenotype switch remain incompletely understood.
In this review, we discuss the role of adipose and liver tissue macrophage-mediated inflammation in experimental and human NAFLD.
This focus is relevant because it may help researchers that approach clinical and experimental studies on this disease advancing the knowledge of mechanisms that could be targeted in order to revert NAFLD-related fibrosis.
American Psychological Association (APA)
Alisi, Anna& Carpino, Guido& de Oliveira, Felipe Leite& Panera, Nadia& Nobili, Valerio& Gaudio, Eugenio. 2017. The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1188746
Modern Language Association (MLA)
Alisi, Anna…[et al.]. The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications. Mediators of Inflammation No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1188746
American Medical Association (AMA)
Alisi, Anna& Carpino, Guido& de Oliveira, Felipe Leite& Panera, Nadia& Nobili, Valerio& Gaudio, Eugenio. The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1188746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188746