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Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells
Joint Authors
Altergot-Ahmad, Olga
Pour, Sarah Jean
Krüssel, Jan-Steffen
Markert, Udo Rudolf
Bielfeld, Alexandra Petra
Fehm, T.
Baston-Büst, D. M.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Successful implantation of the embryo into the human receptive endometrium is substantial for the establishment of a healthy pregnancy.
This study focusses on the role of Syndecan-1 at the embryo-maternal interface, the multitasking coreceptor influencing ligand concentration, release and receptor presentation, and cellular morphology.
CXC motif ligand 1, being involved in chemotaxis and angiogenesis during implantation, is of special interest as a ligand of Syndecan-1.
Human endometrial stromal cells with and without Syndecan-1 knock-down were decidualized and treated with specific inhibitors to evaluate signaling pathways regulating CXC ligand 1 expression.
Western blot analyses of MAPK and Wnt members were performed, followed by analysis of spheroid interactions between human endometrial cells and extravillous trophoblast cells.
By mimicking embryo contact using IL-1β, we showed less ERK and c-Jun activation by depletion of Syndecan-1 and less Frizzled 4 production as part of the canonical Wnt pathway.
Additionally, more beta-catenin was phosphorylated and therefore degraded after depletion of Syndecan-1.
Secretion of CXC motif ligand 1 depends on MEK-1 with respect to Syndecan-1.
Regarding the interaction of endometrial and trophoblast cells, the spheroid center-to-center distances were smaller after depletion of Syndecan-1.
Therefore, Syndecan-1 seems to affect signaling processes relevant to signaling and intercellular interaction at the trophoblast-decidual interface.
American Psychological Association (APA)
Baston-Büst, D. M.& Altergot-Ahmad, Olga& Pour, Sarah Jean& Krüssel, Jan-Steffen& Markert, Udo Rudolf& Fehm, T.…[et al.]. 2017. Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188758
Modern Language Association (MLA)
Baston-Büst, D. M.…[et al.]. Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188758
American Medical Association (AMA)
Baston-Büst, D. M.& Altergot-Ahmad, Olga& Pour, Sarah Jean& Krüssel, Jan-Steffen& Markert, Udo Rudolf& Fehm, T.…[et al.]. Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188758