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Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment
Joint Authors
Ledesma-Soto, Yadira
Peón, Alberto N.
Sciutto, Edda
Olguín, Jonadab E.
Bautista-Donis, Marcel
Terrazas, Luis I.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-28
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
A negative correlation between the geographical distribution of autoimmune diseases and helminth infections has been largely associated in the last few years with a possible role for such type of parasites in the regulation of inflammatory diseases, suggesting new pathways for drug development.
However, few helminth-derived immunomodulators have been tested in experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease multiple sclerosis (MS).
The immunomodulatory activities of Taenia crassiceps excreted/secreted products (TcES) that may suppress EAE development were sought for.
Interestingly, it was discovered that TcES was able to suppress EAE development with more potency than dexamethasone; moreover, TcES treatment was still effective even when inoculated at later stages after the onset of EAE.
Importantly, the TcES treatment was able to induce a range of Th2-type cytokines, while suppressing Th1 and Th17 responses.
Both the polyclonal and the antigen-specific proliferative responses of lymphocytes were also inhibited in EAE-ill mice receiving TcES in association with a potent recruitment of suppressor cell populations.
Peritoneal inoculation of TcES was able to direct the normal inflammatory cell traffic to the site of injection, thus modulating CNS infiltration, which may work along with Th2 immune polarization and lymphocyte activation impairment to downregulate EAE development.
American Psychological Association (APA)
Peón, Alberto N.& Ledesma-Soto, Yadira& Olguín, Jonadab E.& Bautista-Donis, Marcel& Sciutto, Edda& Terrazas, Luis I.. 2017. Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188778
Modern Language Association (MLA)
Peón, Alberto N.…[et al.]. Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment. Mediators of Inflammation No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1188778
American Medical Association (AMA)
Peón, Alberto N.& Ledesma-Soto, Yadira& Olguín, Jonadab E.& Bautista-Donis, Marcel& Sciutto, Edda& Terrazas, Luis I.. Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188778