Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients
Joint Authors
Akin, Ibrahim
Stach, Ksenija
Karb, Susanne
Kälsch, Thorsten
Kälsch, Anna-Isabelle
Borggrefe, Martin
Krämer, Bernhard K.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
The predominant cause of mortality in dialysis patients are cardiovascular events.
Platelet and monocyte activity markers play an important role in cardiovascular mortality and were assessed and related to dialysis quality criteria in haemodialysis (HD) and peritoneal dialysis (PD) patients.
Methods.
For this prospective comparative study, HD patients (n=41) and PD patients (n=10) were included.
In whole blood samples, surface expression of CD62P and CD40L on platelets, tissue factor binding on monocytes, and platelet-monocyte aggregates were measured by flow cytometry.
Plasma levels of MCP-1, IL-6, TNFα, and soluble CD40L were analysed by enzyme-linked immunosorbent assay.
Results.
Haemodialysis patients showed a significantly higher CD62P expression on platelets (p=0.017), significantly higher amount of platelet-monocyte aggregates (p<0.0001), and significantly more tissue factor binding on monocytes (p<0.0001) compared to PD patients.
In PD patients, a significant correlation between Kt/V and platelet CD40L expression (r=0.867; 0.001) and between Kt/V and platelet CD62P expression (r=0.686; p=0.028) was observed, while there was no significant correlation between Kt/V and tissue factor binding on monocytes and platelet-monocyte aggregates, respectively.
Conclusion.
Platelet and monocyte activity markers are higher in HD patients in comparison with those in PD patients, possibly suggesting a higher risk of cardiovascular morbidity and mortality.
American Psychological Association (APA)
Stach, Ksenija& Karb, Susanne& Akin, Ibrahim& Borggrefe, Martin& Krämer, Bernhard K.& Kälsch, Thorsten…[et al.]. 2017. Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1188780
Modern Language Association (MLA)
Stach, Ksenija…[et al.]. Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients. Mediators of Inflammation No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1188780
American Medical Association (AMA)
Stach, Ksenija& Karb, Susanne& Akin, Ibrahim& Borggrefe, Martin& Krämer, Bernhard K.& Kälsch, Thorsten…[et al.]. Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1188780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188780