Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Infection with M.
tuberculosis remains one of the most common infections in the world.
The outcome of the infection depends on host ability to mount effective protection and balance inflammatory responses.
Neutrophils are innate immune cells implicated in both processes.
Accordingly, during M.
tuberculosis infection, they play a dual role.
Particularly, they contribute to the generation of effector T cells, participate in the formation of granuloma, and are directly involved in tissue necrosis, destruction, and infection dissemination.
Neutrophils have a high bactericidal potential.
However, data on their ability to eliminate M.
tuberculosis are controversial, and the results of neutrophil depletion experiments are not uniform.
Thus, the overall roles of neutrophils during M.
tuberculosis infection and factors that determine these roles are not fully understood.
This review analyzes data on neutrophil defensive and pathological functions during tuberculosis and considers hypotheses explaining the dualism of neutrophils during M.
tuberculosis infection and tuberculosis disease.
American Psychological Association (APA)
Lyadova, I. V.. 2017. Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188786
Modern Language Association (MLA)
Lyadova, I. V.. Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188786
American Medical Association (AMA)
Lyadova, I. V.. Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188786