The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract
Joint Authors
Mach, Tomasz
Magierowski, Marcin
Jasnos, Katarzyna
Wojcik, Dagmara
Zahradnik-Bilska, Janina
Mazur-Bialy, Agnieszka
Bilski, Jan
Brzozowski, Bartosz
Brzozowski, Tomasz
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Over the past few years, the role of intestinal alkaline phosphatase (IAP) as a crucial mucosal defence factor essential for maintaining gut homeostasis has been established.
IAP is an important apical brush border enzyme expressed throughout the gastrointestinal tract and secreted both into the intestinal lumen and into the bloodstream.
IAP exerts its effects through dephosphorylation of proinflammatory molecules including lipopolysaccharide (LPS), flagellin, and adenosine triphosphate (ATP) released from cells during stressful events.
Diminished activity of IAP could increase the risk of disease through changes in the microbiome, intestinal inflammation, and intestinal permeability.
Exogenous IAP exerts a protective effect against intestinal and systemic inflammation in a variety of diseases and represents a potential therapeutic agent in diseases driven by gut barrier dysfunction such as IBD.
The intestinal protective mechanisms are impaired in IBD patients due to lower synthesis and activity of endogenous IAP, but the pathomechanism of this enzyme deficiency remains unclear.
IAP has been safely administered to humans and the human recombinant form of IAP has been developed.
This review was designed to provide an update in recent research on the involvement of IAP in intestinal inflammatory processes with focus on IBD in experimental animal models and human patients.
American Psychological Association (APA)
Bilski, Jan& Mazur-Bialy, Agnieszka& Wojcik, Dagmara& Zahradnik-Bilska, Janina& Brzozowski, Bartosz& Magierowski, Marcin…[et al.]. 2017. The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188806
Modern Language Association (MLA)
Bilski, Jan…[et al.]. The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188806
American Medical Association (AMA)
Bilski, Jan& Mazur-Bialy, Agnieszka& Wojcik, Dagmara& Zahradnik-Bilska, Janina& Brzozowski, Bartosz& Magierowski, Marcin…[et al.]. The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188806