IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex
Joint Authors
Yoon, Sik
Goh, Tae Sik
Jo, Yuna
Lee, Byunghyuk
Kim, Geona
Hwang, Hyunju
Ko, Eunhee
Kang, Seung Wan
Oh, Sae-Ock
Baek, Sun-Yong
Lee, Jung Sub
Hong, Changwan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
IL-7 signaling via IL-7Rα and common γ-chain (γc) is necessary for the development and homeostasis of T cells.
Although the delicate mechanism in which IL-7Rα downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-7Rα and γc in the absence or presence of IL-7 remains unclear.
Additionally, we are still uncertain as to how only IL-7Rα is separately downregulated by the binding of IL-7 from the IL-7Rα/γc complex.
We demonstrate here that 4G3, TUGm2, and 3E12 epitope masking of γc protein are induced in the presence of IL-7, indicating that the epitope alteration is induced by IL-7 binding to the preassembled receptor core.
Moreover, the epitope masking of γc protein is inversely correlated with the expression of IL-7Rα upon IL-7 binding, implying that the structural alteration of γc might be involved in the regulation of IL-7Rα expression.
The conformational change in γc upon IL-7 binding may contribute not only to forming the functional IL-7 signaling complex but also to optimally regulating the expression of IL-7Rα.
American Psychological Association (APA)
Goh, Tae Sik& Jo, Yuna& Lee, Byunghyuk& Kim, Geona& Hwang, Hyunju& Ko, Eunhee…[et al.]. 2017. IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188808
Modern Language Association (MLA)
Goh, Tae Sik…[et al.]. IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188808
American Medical Association (AMA)
Goh, Tae Sik& Jo, Yuna& Lee, Byunghyuk& Kim, Geona& Hwang, Hyunju& Ko, Eunhee…[et al.]. IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188808