Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia
Joint Authors
Zhang, Xiaobao
Yan, Fang
Cui, Jizheng
Wu, Yong
Luan, Hengfei
Yin, Miaomiao
Zhao, Zhibin
Feng, Jiying
Zhang, Jinwei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Microglia play an important role in mediating inflammatory processes in the central nervous system (CNS).
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor and could decrease neuropathology in Alzheimer’s disease (AD).
However, the detailed mechanism remains unclear.
This study was designed to elucidate the effect of TREM2 on microglia.
We showed that lipopolysaccharide (LPS) stimulation significantly increases proinflammatory cytokines and suppressed TREM2 in microglia.
In addition, TREM2 overexpression inhibited LPS-induced microglia activation and elevated M2 phenotype of microglia.
Together, our results demonstrate that TREM2 overexpression reduced LPS-induced proinflammatory cytokine release in microglia and increased M2 phenotype of microglia.
These findings provide novel insights that the regulation of microglia polarization may be an approach for ameliorating microglia inflammation in neurodegenerative diseases.
American Psychological Association (APA)
Zhang, Xiaobao& Yan, Fang& Cui, Jizheng& Wu, Yong& Luan, Hengfei& Yin, Miaomiao…[et al.]. 2017. Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1188817
Modern Language Association (MLA)
Zhang, Xiaobao…[et al.]. Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia. Mediators of Inflammation No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1188817
American Medical Association (AMA)
Zhang, Xiaobao& Yan, Fang& Cui, Jizheng& Wu, Yong& Luan, Hengfei& Yin, Miaomiao…[et al.]. Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1188817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188817