Serum Interleukin-23 in Polish Patients with Systemic Lupus Erythematosus: Association with Lupus Nephritis, Obesity, and Peripheral Vascular Disease
Joint Authors
Brzosko, Marek
Fischer, Katarzyna
Przepiera-Będzak, Hanna
Sawicki, Marcin
Walecka, Anna
Brzosko, Iwona
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
To analyze the correlation between the serum concentration of interleukin- (IL-) 23 and atherosclerotic changes, traditional atherosclerotic risk factors, the autoantibody profile, and involvement of selected organs in systemic lupus erythematosus (SLE) patients.
Patients and Methods.
We studied 94 SLE patients and 27 controls.
We analyzed the IL-23 serum concentration, autoantibodies, carotid intima-media thickness and atherosclerotic plaque, the ankle-brachial index, atherosclerotic risk factors, and organ manifestations.
Results.
Concentrations of IL-23 significantly differed between SLE patients and the controls (p=0.0015).
On the basis of multivariate stepwise analysis, we revealed that high levels of IL-23 were associated with atherosclerotic plaque in common femoral arteries (OR = 12.67; 95% CI: 1.41–113.84), lupus nephritis (OR = 3.69; 95% CI: 1.16–12.22), and obesity (OR = 4.21; 95% CI: 1.40–12.67).
Autoantibodies related to IL-23 were anti-phosphatidylethanolamine antibodies (OR = 11.06; 95% CI: 1.24–98.65) and anti-SS-B/La antibodies (OR = 15.43; 95% CI: 1.73–137.25).
Conclusions.
IL-23 may be involved in lupus nephritis pathogenesis.
Through its association with obesity and selected antiphospholipid antibodies, IL-23 might promote a hypercoagulable state contributing to atherothrombosis development in SLE patients.
American Psychological Association (APA)
Fischer, Katarzyna& Przepiera-Będzak, Hanna& Sawicki, Marcin& Walecka, Anna& Brzosko, Iwona& Brzosko, Marek. 2017. Serum Interleukin-23 in Polish Patients with Systemic Lupus Erythematosus: Association with Lupus Nephritis, Obesity, and Peripheral Vascular Disease. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188821
Modern Language Association (MLA)
Fischer, Katarzyna…[et al.]. Serum Interleukin-23 in Polish Patients with Systemic Lupus Erythematosus: Association with Lupus Nephritis, Obesity, and Peripheral Vascular Disease. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188821
American Medical Association (AMA)
Fischer, Katarzyna& Przepiera-Będzak, Hanna& Sawicki, Marcin& Walecka, Anna& Brzosko, Iwona& Brzosko, Marek. Serum Interleukin-23 in Polish Patients with Systemic Lupus Erythematosus: Association with Lupus Nephritis, Obesity, and Peripheral Vascular Disease. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188821