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Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Joint Authors
Aukrust, Pål
Dhondup, Yangchen
Sjaastad, Ivar
Sandanger, Øystein
Aronsen, Jan Magnus
Ahmed, Muhammad Shakil
Attramadal, Håvard
Finsen, Alexandra Vanessa
Zhang, Lili
Ranheim, Trine
Alfsnes, Katrine
Christensen, Geir
Yndestad, Arne
Vinge, Leif Erik
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aim.
Inflammation is important in heart failure (HF).
The role of the immune receptor toll-like receptor 9 (TLR9) in HF is not understood and not investigated in diastolic HF.
We investigated the role of TLR9 in a murine diastolic HF model caused by cardiomyocyte SERCA2a excision.
Methods and Results.
We crossed SERCA2a KO and TLR9 KO mice to generate four mouse lines.
Tamoxifen-induced cardiomyocyte SERCA2a gene excision was carried out in mice, causing diastolic HF.
After 7.6 weeks, cardiac functions and dimensions were analyzed by echocardiography and heart tissues were processed.
HF mice depleted of TLR9 demonstrated reduced survival compared to SERC2a KO mice, with a median life expectancy of 58 days compared to 63 days.
Both HF groups displayed increased left atrium size, lung weight, fetal gene expressions, monocyte/macrophage infiltration, and fibrosis.
However, there were no significant differences between the groups.
Conclusion.
In mice with SERCA2a KO-induced diastolic HF, the absence of TLR9 reduced median life expectancy.
The cause remains elusive, as all investigated HF parameters were unaltered.
Still, these findings support a salutary role of TLR9 in some subsets of HF conditions and underline the importance for future studies on the mechanisms of TLR9 in diastolic HF.
American Psychological Association (APA)
Dhondup, Yangchen& Sjaastad, Ivar& Sandanger, Øystein& Aronsen, Jan Magnus& Ahmed, Muhammad Shakil& Attramadal, Håvard…[et al.]. 2017. Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188824
Modern Language Association (MLA)
Dhondup, Yangchen…[et al.]. Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188824
American Medical Association (AMA)
Dhondup, Yangchen& Sjaastad, Ivar& Sandanger, Øystein& Aronsen, Jan Magnus& Ahmed, Muhammad Shakil& Attramadal, Håvard…[et al.]. Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188824