Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System
Joint Authors
Bollaerts, Ilse
Van houcke, Jessie
Andries, Lien
De Groef, Lies
Moons, Lieve
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited capacity of CNS regeneration.
The causes underlying this limited regenerative potential are multifactorial, but one critical aspect is neuroinflammation.
Although classically considered as harmful, it is now becoming increasingly clear that inflammation can also promote regeneration, if the appropriate context is provided.
Here, we review the current knowledge on how acute inflammation is intertwined with axonal regeneration, an important component of CNS repair.
After optic nerve or spinal cord injury, inflammatory stimulation and/or modification greatly improve the regenerative outcome in rodents.
Moreover, the hypothesis of a beneficial role of inflammation is further supported by evidence from adult zebrafish, which possess the remarkable capability to repair CNS lesions and even restore functionality.
Lastly, we shed light on the impact of aging processes on the regenerative capacity in the CNS of mammals and zebrafish.
As aging not only affects the CNS, but also the immune system, the regeneration potential is expected to further decline in aged individuals, an element that should definitely be considered in the search for novel therapeutic strategies.
American Psychological Association (APA)
Bollaerts, Ilse& Van houcke, Jessie& Andries, Lien& De Groef, Lies& Moons, Lieve. 2017. Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188827
Modern Language Association (MLA)
Bollaerts, Ilse…[et al.]. Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188827
American Medical Association (AMA)
Bollaerts, Ilse& Van houcke, Jessie& Andries, Lien& De Groef, Lies& Moons, Lieve. Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188827