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Toll-Like Receptor 4 Signalling and Its Impact on Platelet Function, Thrombosis, and Haemostasis
Joint Authors
Vaiyapuri, Sakthivel
Zeuner, Marie-Theres
Vallance, Thomas
Williams, Harry F.
Widera, Darius
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Platelets are anucleated blood cells that participate in a wide range of physiological and pathological functions.
Their major role is mediating haemostasis and thrombosis.
In addition to these classic functions, platelets have emerged as important players in the innate immune system.
In particular, they interact with leukocytes, secrete pro- and anti-inflammatory factors, and express a wide range of inflammatory receptors including Toll-like receptors (TLRs), for example, Toll-like receptor 4 (TLR4).
TLR4, which is the most extensively studied TLR in nucleated cells, recognises lipopolysaccharides (LPS) that are compounds of the outer surface of Gram-negative bacteria.
Unlike other TLRs, TLR4 is able to signal through both the MyD88-dependent and MyD88-independent signalling pathways.
Notably, despite both pathways culminating in the activation of transcription factors, TLR4 has a prominent functional impact on platelet activity, haemostasis, and thrombosis.
In this review, we summarise the current knowledge on TLR4 signalling in platelets, critically discuss its impact on platelet function, and highlight the open questions in this area.
American Psychological Association (APA)
Vallance, Thomas& Zeuner, Marie-Theres& Williams, Harry F.& Widera, Darius& Vaiyapuri, Sakthivel. 2017. Toll-Like Receptor 4 Signalling and Its Impact on Platelet Function, Thrombosis, and Haemostasis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188832
Modern Language Association (MLA)
Vallance, Thomas…[et al.]. Toll-Like Receptor 4 Signalling and Its Impact on Platelet Function, Thrombosis, and Haemostasis. Mediators of Inflammation No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1188832
American Medical Association (AMA)
Vallance, Thomas& Zeuner, Marie-Theres& Williams, Harry F.& Widera, Darius& Vaiyapuri, Sakthivel. Toll-Like Receptor 4 Signalling and Its Impact on Platelet Function, Thrombosis, and Haemostasis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188832