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Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-02
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Since its discovery, ADAM17, also known as TNFα converting enzyme or TACE, is now known to process over 80 different substrates.
Many of these substrates are mediators of cancer and inflammation.
The field of ADAM metalloproteinases is at a crossroad with many of the new potential therapeutic agents for ADAM17 advancing into the clinic.
Researchers have now developed potential drugs for ADAM17 that are selective and do not have the side effects which were seen in earlier chemical entities that targeted this enzyme.
ADAM17 inhibitors have broad therapeutic potential, with properties ranging from tumor immunosurveillance and overcoming drug and radiation resistance in cancer, as treatments for cardiac hypertrophy and inflammatory conditions such as inflammatory bowel disease and rheumatoid arthritis.
This review focuses on substrates and inhibitors identified more recently for ADAM17 and their role in cancer and inflammation.
American Psychological Association (APA)
Moss, Marcia L.& Minond, Dmitry. 2017. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1188837
Modern Language Association (MLA)
Moss, Marcia L.& Minond, Dmitry. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators of Inflammation No. 2017 (2017), pp.1-21.
https://search.emarefa.net/detail/BIM-1188837
American Medical Association (AMA)
Moss, Marcia L.& Minond, Dmitry. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1188837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188837