Comparison of Transcatheter Arterial Chemoembolization-Radiofrequency Ablation and Transcatheter Arterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma with Macrovascular Invasion Using Propensity Score Analysis: A Retrospective Cohort Study
Joint Authors
Liu, Yao
Gao, Fangyuan
Yang, Xue
Li, Yuxin
Zhang, Qun
Niu, Shuaishuai
Huang, Yunyi
Hu, Ying
Wang, Xianbo
Zhu, Bingbing
Li, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
To compare the efficacies of transcatheter arterial chemoembolization (TACE) with radiofrequency ablation (RFA) (TACE + RFA) and TACE alone in patients with hepatocellular carcinoma (HCC) and macrovascular invasion (MVI).
Methods.
In total, 664 patients having HCC with MVI were included.
Of these patients, 141 were treated with TACE + RFA, 254 with TACE alone, and 269 with supportive therapy (control group).
The overall survival (OS) was compared among these groups.
Propensity score matching (PSM) was performed for balancing the characteristics of the three groups.
Results.
After one-to-one PSM, the 12-month OS rates were higher in the TACE and TACE + RFA groups than in the control group (p=0.0009 and p=0.0017, respectively).
Furthermore, higher 12-month OS rates were observed in the TACE + RFA group than in the TACE group (p=0.0192).
The 12-month OS rates of patients were remarkably higher in α-fetoprotein (AFP) < 400 ng/ml, tumor < 3, tumor diameter < 5 cm, or portal vein tumor thrombosis (PVTT) group who were treated with TACE + RFA than in those who were treated with TACE (p=0.0122, p=0.0090, p=0112, and p=0.0071, respectively).
Conclusions.
TACE + RFA provides a superior survival outcome than TACE alone in HCC patients, especially in AFP <400 ng/ml, tumor <3, tumor diameter <5 cm, or PVTT group.
American Psychological Association (APA)
Liu, Yao& Li, Yuxin& Gao, Fangyuan& Zhang, Qun& Yang, Xue& Zhu, Bingbing…[et al.]. 2020. Comparison of Transcatheter Arterial Chemoembolization-Radiofrequency Ablation and Transcatheter Arterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma with Macrovascular Invasion Using Propensity Score Analysis: A Retrospective Cohort Study. Journal of Oncology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188842
Modern Language Association (MLA)
Liu, Yao…[et al.]. Comparison of Transcatheter Arterial Chemoembolization-Radiofrequency Ablation and Transcatheter Arterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma with Macrovascular Invasion Using Propensity Score Analysis: A Retrospective Cohort Study. Journal of Oncology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1188842
American Medical Association (AMA)
Liu, Yao& Li, Yuxin& Gao, Fangyuan& Zhang, Qun& Yang, Xue& Zhu, Bingbing…[et al.]. Comparison of Transcatheter Arterial Chemoembolization-Radiofrequency Ablation and Transcatheter Arterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma with Macrovascular Invasion Using Propensity Score Analysis: A Retrospective Cohort Study. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188842