Prognostic Significance of Tumor Tissue NeuGcGM3 Ganglioside Expression in Patients Receiving Racotumomab Immunotherapy
Joint Authors
Baloglu, Huseyin
Uskent, Necdet
Ayla, Sule
Ozkan, Metin
Teomete, Mehmet
Aydıncer, Cenk
Yergok, Hale
Dogan, Ender
Berk, Barkın
Yazar, Aziz
Mandel, Nil Molinas
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Expression of N-glycolyl GM3 (NeuGcGM3) ganglioside was detected in the tumor specimens of patients who were on Racotumomab anti-idiotype vaccine maintenance treatment, and prognostic significance as a biomarker was investigated.
No statistically significant association was observed in the multivariate analysis between overall survival and tissue NeuGcGM3 IHC levels.
Although numerically there was a difference favoring less intense IHC for better prognosis, this did not reach statistical power.
However, there was a strong correlation between Racotumomab doses and overall survival (OS).
Mean OS of the patient with more than 10 Racotumomab application was significantly longer than the patient who had less than 10 injections (70.7 months vs.
31.1 months, p<0.001).
We propose that, regardless of staining intensity, the presence of NeuGcGM3 in patient tissues might be an indicator of benefit in Racotumomab treatment.
American Psychological Association (APA)
Uskent, Necdet& Ayla, Sule& Mandel, Nil Molinas& Ozkan, Metin& Teomete, Mehmet& Baloglu, Huseyin…[et al.]. 2020. Prognostic Significance of Tumor Tissue NeuGcGM3 Ganglioside Expression in Patients Receiving Racotumomab Immunotherapy. Journal of Oncology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1188843
Modern Language Association (MLA)
Uskent, Necdet…[et al.]. Prognostic Significance of Tumor Tissue NeuGcGM3 Ganglioside Expression in Patients Receiving Racotumomab Immunotherapy. Journal of Oncology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1188843
American Medical Association (AMA)
Uskent, Necdet& Ayla, Sule& Mandel, Nil Molinas& Ozkan, Metin& Teomete, Mehmet& Baloglu, Huseyin…[et al.]. Prognostic Significance of Tumor Tissue NeuGcGM3 Ganglioside Expression in Patients Receiving Racotumomab Immunotherapy. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1188843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188843